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Compound reference

Citrulline Malate

L-Citrulline

Ancillary compounds1 cited findingClinical review: not reviewed

Clinical & experimental findings

Human randomized studyAbstract inspected

A randomized, double-blind crossover study in 41 men found a single 8 g dose of citrulline malate increased bench-press repetitions progressively across sets, reaching 52.92% more repetitions by the final set (P<.0001), and reduced muscle soreness by about 40% at 24 and 48 hours; 14.63% of participants reported stomach discomfort. It did not establish long-term benefit or equivalence to L-citrulline alone.[1]

  • One acute exercise protocol and a single 8 g dose; formulation and task matter, and no long-term outcome was measured.
  • Abstract-checked; no qualified clinical review.
Inspection history

Clinical review: not reviewed by a qualified clinician.

· Independent source inspection; applicability narrowed and inherited assertions excluded where unsupported. No qualified clinical review.

· Reopened the PubMed structured abstract via E-utilities and added the exact repetition, soreness and adverse-event percentages. No PMC full text available. Independent editorial review pending; no qualified clinical review.

What remains unresolved

Editorial assessment

These notes describe the scope of this review. Linked PMIDs are audit identifiers; an identifier alone does not verify a claim.

Narrowly supported passages published with study/product limits; remaining inherited assertions withheld from established-fact displays.

  • Not a comprehensive systematic review. Original monograph topics beyond the individual published claims—including monitoring schedules, contraindication lists, recovery assurances and detailed mechanisms—remain unverified.
  • No qualified clinician has reviewed these claims. Long-term outcomes and all marketed formulations have not been fully assessed.

This reference does not supply a dosing plan, monitoring timetable or recovery regimen. Discuss personal symptoms, medicines and laboratory results with a qualified clinician.

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References

  1. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness.

    Perez-Guisado J, Jakeman PM. J Strength Cond Res. 2010 May;24(5):1215-1222. doi: 10.1519/JSC.0b013e3181cb28e0. 2010-05. PMID:20386132 · DOI:10.1519/JSC.0b013e3181cb28e0 Abstract only.

    Inspected location: PubMed abstract (full structured text): repetitions-to-fatigue by set, soreness reduction at 24/48 h, adverse-event rate

    Study context and inspection record

Source inspection and clinical review are separate. An abstract check is not a full-text review. The records above identify what was actually inspected and do not certify the complete literature.

Recorded verification attempts
  • Fresh PubMed EUtils retrieval for inherited lead PMID 20386132; identity, abstract and linked corrections checked where an abstract existed.
  • https://pubmed.ncbi.nlm.nih.gov/20386132/ — abstract; PubMed abstract: Results: bench-press repetitions, soreness and stomach discomfort

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Related records in this class

Grouped under Ancillary compounds for navigation only. Shared class membership does not make findings, formulations or evidence interchangeable between records.

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