Safety information

Call the local emergency number (911 in the US) for collapse, inability to breathe or unresponsiveness. For suspected poisoning, get help immediately; in the US call Poison Help at 1-800-222-1222. Do not give an unconscious person anything by mouth, and do not induce vomiting unless instructed by poison control or a health care professional.^[1][2]

• General first-aid guidance, not a complete symptom list or treatment protocol; use local emergency services outside the US.

A study of male weightlifters associated long-term mixed AAS exposure with lower left-ventricular function and greater coronary plaque volume than in non-users. The observational design cannot isolate an individual steroid or prove a precise risk of heart attack.^[3]

• Class-context evidence from selected male weightlifters; residual confounding and uncertain historical exposures remain.
• This finding and the interaction file's "safety-aas-cardiovascular" note rest on the same single study, held under two source records. Seeing both is not two studies agreeing.

TRAVERSE found testosterone gel noninferior to placebo for major cardiovascular events in selected men with hypogonadism and cardiovascular risk. Atrial fibrillation, acute kidney injury and pulmonary embolism occurred more often with testosterone, but these findings had different endpoint ascertainment and statistical limits from the primary result. The study did not test injectable-AAS misuse.^[4]

• Formulation and clinical population differ from injectable or supraphysiologic nonmedical use.
• AF/AKI were investigator-reported adverse events; PE belonged to the adjudicated tertiary VTE endpoint. No multiplicity adjustment for other endpoints.

LiverTox's Androgenic Steroids chapter individually names methandrostenolone (Dianabol), oxymetholone (Anadrol), fluoxymesterone (Halotestin), stanozolol (Winstrol) and oxandrolone (Anavar) among the C-17-alpha-alkylated steroids it says "have all been implicated in cases of liver injury, including prolonged cholestasis, peliosis hepatis, nodular regeneration, hepatic adenomas and hepatocellular carcinoma," and estimates that acute cholestasis occurs in roughly 1% of patients treated specifically with methyltestosterone, danazol, stanozolol or oxymetholone. Methasterone (Superdrol) is not named in that class-level narrative; LiverTox links it to liver injury only through separately cited case-report literature. This class context does not establish an equal, quantified risk for every one of these six compounds, formulations or exposures.^[5]

• Class-level synthesis; no product-specific event rate and no evidence that supplements prevent injury.
• The approximate 1% acute-cholestasis estimate applies only to methyltestosterone, danazol, stanozolol and oxymetholone; it is not stated for methandrostenolone, fluoxymesterone, oxandrolone or methasterone.
• Methasterone/Superdrol's connection to this LiverTox chapter runs through cited case-report literature (including the same methasterone case series relied on elsewhere in this dossier), not the chapter's own class-level narrative naming used for the other five compounds.

FDA reports serious liver injury and other serious reactions involving steroid or steroid-like bodybuilding products. It advises immediately consulting a healthcare professional, including before abrupt cessation, because of dangerous withdrawal problems that can arise from quickly stopping such products.^[6]

• General product safety communication, not an incidence estimate for every listed steroid.

In the HAARLEM cohort of men using mixed anabolic-androgenic steroids, testosterone and sperm recovery differed. The final visit was one year after cycle start, not one year after cessation, and some abnormal final results were already present at baseline. The study did not measure pregnancy or live birth and does not provide a universal recovery deadline.^[7]

• Class-context evidence: mixed exposures cannot isolate any individual molecule or ester, and follow-up was too short to characterize all recovery.
• Final hormone and semen denominators differ; attrition and resumed use limit recovery inference.

Insulin can cause life-threatening hypoglycemia; HUMALOG labeling separately states that all insulins, including HUMALOG, can cause a shift in potassium that may lead to hypokalemia, which can cause respiratory paralysis, ventricular arrhythmia and death. HUMALOG labeling requires close medical supervision for regimen changes. Rapid- and long-acting insulin may be prescribed together; their presence alone is not a contraindicated combination.^[8]

• Insulin formulations have different action profiles; the inspected product label is HUMALOG.
• This site does not calculate insulin doses or provide a rescue regimen.

DNP is a toxic industrial chemical with documented fatal poisonings; since 2023 it is also a licensed/regulated poison in the UK, and unlicensed sale to the public is a criminal offence. Seek immediate medical or poison-service advice after taking it. This intrinsic hazard applies even when the checker has no interaction entry.^[9][10]

• Toxicity evidence does not create a documented contraindication between DNP and every other compound.
• The UK guidance page shows only its original 2017 publish date despite describing a 2023 law change, so its true last-revision date is not separately confirmed.