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Compound reference

Curcumin

Turmeric extract

Ancillary compounds1 cited findingClinical review: not reviewed

Pharmacokinetics

Human observational studyAbstract inspected

A human pharmacokinetic experiment found curcumin alone (2 g) produced undetectable or very low serum levels, while coadministration with a single 20 mg dose of piperine increased human bioavailability by a reported 2000%, with the effect appearing within 0.25 to 1 hour. Enhanced absorption with this specific low-dose piperine pairing is a formulation finding, not evidence of improved clinical outcomes, and does not show that other enhanced formulations behave the same way.[1]

  • Small pharmacokinetic experiment with an unspecified human sample size; piperine-containing and other enhanced formulations (phospholipid complexes, nanoparticle/micellar curcumin) are not interchangeable.
  • Abstract-checked; no qualified clinical review.
Inspection history

Clinical review: not reviewed by a qualified clinician.

· Independent source inspection; applicability narrowed and inherited assertions excluded where unsupported. No qualified clinical review.

· Reopened the PubMed structured abstract via E-utilities and added the exact reported bioavailability increases (rats +154%, humans +2000%) and timing. No PMC full text available. Independent editorial review pending; no qualified clinical review.

What remains unresolved

Editorial assessment

These notes describe the scope of this review. Linked PMIDs are audit identifiers; an identifier alone does not verify a claim.

Narrowly supported passages published with study/product limits; remaining inherited assertions withheld from established-fact displays.

  • Not a comprehensive systematic review. Original monograph topics beyond the individual published claims—including monitoring schedules, contraindication lists, recovery assurances and detailed mechanisms—remain unverified.
  • No qualified clinician has reviewed these claims. Long-term outcomes and all marketed formulations have not been fully assessed.

This reference does not supply a dosing plan, monitoring timetable or recovery regimen. Discuss personal symptoms, medicines and laboratory results with a qualified clinician.

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References

  1. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers.

    Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Planta Med. 1998 May;64(4):353-356. 1998-05. PMID:9619120 Abstract only.

    Inspected location: PubMed abstract (full structured text): rat pharmacokinetic results with 2 g/kg curcumin +/- 20 mg/kg piperine; human results with 2 g curcumin +/- 20 mg piperine

    Study context and inspection record

Source inspection and clinical review are separate. An abstract check is not a full-text review. The records above identify what was actually inspected and do not certify the complete literature.

Recorded verification attempts
  • Fresh PubMed EUtils retrieval for inherited lead PMID 9619120; identity, abstract and linked corrections checked where an abstract existed.
  • https://pubmed.ncbi.nlm.nih.gov/9619120/ — abstract; PubMed abstract: Human pharmacokinetic results: curcumin alone compared with piperine coadministration

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Related records in this class

Grouped under Ancillary compounds for navigation only. Shared class membership does not make findings, formulations or evidence interchangeable between records.

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