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Compound reference

Creatine Monohydrate

Creatine

Ancillary compounds1 cited findingClinical review: not reviewed

Safety findings

Human randomized studyAbstract inspected

A three-month, randomized, double-blind, placebo-controlled study in 18 healthy sedentary men undertaking aerobic training found cystatin C fell over time in both the creatine (about 10 g/day) and placebo groups (P=.0001 for the time effect), which the authors interpreted as training-related improvement rather than harm; serum creatinine fell with training in the placebo group but was unchanged with creatine. This small study cannot establish safety in kidney disease, high-dose loading protocols, or exclude uncommon harms.[1]

  • Small (n=18) study with laboratory outcomes in healthy sedentary men; not a blanket renal-safety guarantee and does not test people with kidney disease or high-dose loading protocols.
  • Abstract-checked; no qualified clinical review.
Inspection history

Clinical review: not reviewed by a qualified clinician.

· Independent source inspection; applicability narrowed and inherited assertions excluded where unsupported. No qualified clinical review.

· Reopened the PubMed structured abstract via E-utilities, confirmed the Randomized Controlled Trial publication-type tag, and added exact cystatin C/creatinine values. No PMC full text available. Independent editorial review pending; no qualified clinical review.

What remains unresolved

Editorial assessment

These notes describe the scope of this review. Linked PMIDs are audit identifiers; an identifier alone does not verify a claim.

Narrowly supported passages published with study/product limits; remaining inherited assertions withheld from established-fact displays.

  • Not a comprehensive systematic review. Original monograph topics beyond the individual published claims—including monitoring schedules, contraindication lists, recovery assurances and detailed mechanisms—remain unverified.
  • No qualified clinician has reviewed these claims. Long-term outcomes and all marketed formulations have not been fully assessed.

This reference does not supply a dosing plan, monitoring timetable or recovery regimen. Discuss personal symptoms, medicines and laboratory results with a qualified clinician.

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References

  1. Effects of creatine supplementation on renal function: a randomized, double-blind, placebo-controlled clinical trial.

    Gualano B, Ugrinowitsch C, Novaes RB, Artioli GG, Shimizu MH, Seguro AC, Harris RC, Lancha AH Jr. Eur J Appl Physiol. 2008 May;103(1):33-40. doi: 10.1007/s00421-007-0669-3. 2008-05. PMID:18188581 · DOI:10.1007/s00421-007-0669-3 Abstract only.

    Inspected location: PubMed abstract (full structured text): cystatin C, serum creatinine and urinary electrolyte results by group and timepoint

    Study context and inspection record

Source inspection and clinical review are separate. An abstract check is not a full-text review. The records above identify what was actually inspected and do not certify the complete literature.

Recorded verification attempts
  • Fresh PubMed EUtils retrieval for inherited lead PMID 18188581; identity, abstract and linked corrections checked where an abstract existed.
  • https://pubmed.ncbi.nlm.nih.gov/18188581/ — abstract; PubMed abstract: Methods: healthy men and three-month training study; Results: cystatin C and other renal markers

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Related records in this class

Grouped under Ancillary compounds for navigation only. Shared class membership does not make findings, formulations or evidence interchangeable between records.

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