S-23 — Dosing, Cycles, Half-Life & Side Effects
S-23 is a selective androgen receptor modulator (SARM) with a half-life of 12 hours. Potent SARM with high bioavailability for lean mass, causes significant suppression. Primary risks include strong HPTA suppression. This page is educational harm-reduction reference compiled from peer-reviewed literature — not medical advice, not an endorsement, not a recommendation to use. Consult a licensed clinician before any decision.
Quick Facts
| Class | Selective Androgen Receptor Modulator |
|---|---|
| Half-life | 12 hours |
| Detection window | 14 days |
| Aromatization | No |
| Hepatotoxicity | Low |
| Suppression | 7/10 |
| 17α-alkylated | No |
| Administration | oral |
Typical Dosing Ranges
Common dose range: 10-30mg/day
Cycle length: 8-10 weeks
Time to steady state: ~2.5 days
Dose ranges are compiled from published pharmacokinetic studies and community-reported usage. Where a value is community-reported rather than clinically studied, this page and its structured data flag it. Lower end of any range is always the safer starting point.
Stacking Considerations
- No structural stacking blockers. Standard harm-reduction rules apply: minimize total androgen load, minimize oral exposure, and monitor bloodwork.
PCT Requirements
- This compound causes clinically meaningful HPTA suppression. Post-cycle therapy is recommended.
- Depot clearance estimate: ~3 days post-last-dose before SERM start (5 × apparent depot half-life of 12h).
- Never stack two SERMs. Extend a single SERM (tamoxifen OR enclomiphene/clomiphene) rather than combining.
- Use the cycle planner to generate a full protocol based on your complete stack, not this compound alone.
Side Effect Profile
- Significant suppression
- Vision tint (rare)
- Limited research
- May reduce HDL
Known Interactions
RAD-140 (Testolone) + s23
moderate — suppressiveS23 is highly suppressive. Combination may cause significant hormonal disruption.
Recommendation: Test base strongly recommended. PCT required.
Monitor: Full hormone panel
Related compounds
Monitoring (Bloodwork & Vitals)
- Comprehensive metabolic panel (baseline, mid-cycle, post-cycle)
- Lipid panel (total cholesterol, HDL, LDL, triglycerides)
- CBC (hemoglobin, hematocrit — watch for erythrocytosis)
- Sex-hormone panel (Total T, Free T, Estradiol sensitive, SHBG, LH, FSH)
- Blood pressure (weekly self-check; flag systolic >140 or diastolic >90)
Baseline bloodwork is recommended before any cycle. Discontinue if liver enzymes exceed 3× upper limit of normal or if hematocrit exceeds 54%.
Frequently Asked Questions
What is the half-life of S-23?
S-23 has a half-life of approximately 12 hours. Clearance estimate: 12h × 5 = 60h = 2.5 days. This figure is used to determine injection frequency (for esters) and post-cycle clearance timing.
What is the typical dose range for S-23?
Commonly reported ranges for S-23: 10-30mg/day. Cycle length: 8-10 weeks. These are compiled from published studies and community-reported usage — individual response varies and lower end is always preferred.
Does S-23 suppress natural testosterone?
S-23 causes strong suppression of the HPTA axis (score 7/10). Post-cycle therapy (PCT) is recommended after use.
Is S-23 liver toxic?
Hepatotoxicity rating: Low. Non-17αα compound — liver stress is lower but still warrants periodic monitoring during a cycle.
Does S-23 aromatize to estrogen?
Aromatization profile: No. Minimal to no aromatization expected, so aromatase inhibitors are not typically indicated for this compound alone.
What is S-23 typically used for?
S-23 is commonly used for: Cutting, Recomposition, Advanced SARM users. Intended-use context does not imply safety — every use case carries the same underlying pharmacological risks.
Citations
Disclaimer
StackItSmart is an independent harm-reduction reference. The content above is compiled from peer-reviewed literature and is not medical advice, not an endorsement, and not a recommendation to use S-23. Performance-enhancing compounds carry legal, endocrine, cardiovascular, and hepatic risks. Consult a licensed clinician before any decision. StackItSmart does not provide sourcing, procurement, or dosing prescriptions.