Masteron Propionate — Dosing, Cycles, Half-Life & Side Effects
Masteron Propionate is a DHT-derived anabolic-androgenic steroid with a half-life of 2-3 days. DHT derivative for cutting and hardness. This page is educational harm-reduction reference compiled from peer-reviewed literature — not medical advice, not an endorsement, not a recommendation to use. Consult a licensed clinician before any decision.
Quick Facts
| Class | DHT |
|---|---|
| Half-life | 2-3 days |
| Detection window | 30 days |
| Aromatization | No |
| Hepatotoxicity | None |
| Suppression | 3/10 |
| 17α-alkylated | No |
| Administration | injectable |
Typical Dosing Ranges
Common dose range: 350-525mg/week
Cycle length: 8-12 weeks
Time to steady state: ~10 days
Dose ranges are compiled from published pharmacokinetic studies and community-reported usage. Where a value is community-reported rather than clinically studied, this page and its structured data flag it. Lower end of any range is always the safer starting point.
Stacking Considerations
- No structural stacking blockers. Standard harm-reduction rules apply: minimize total androgen load, minimize oral exposure, and monitor bloodwork.
PCT Requirements
- Depot clearance estimate: ~10 days post-last-dose before SERM start (5 × apparent depot half-life of 48h).
- Never stack two SERMs. Extend a single SERM (tamoxifen OR enclomiphene/clomiphene) rather than combining.
- Use the cycle planner to generate a full protocol based on your complete stack, not this compound alone.
Side Effect Profile
- Hair loss
- Frequent injections
- Mild suppression
- Acne
Known Interactions
No compound-specific interactions are catalogued in the current matrix. This does not mean no risk exists — it means there is no curated pairwise entry. Browse the full interaction matrix to cross-reference manually.
Related compounds
Anadrol (Oxymetholone)
Orals · t½ 8-9 hours
Anavar (Oxandrolone)
Orals · t½ 8-9 hours
Deca Durabolin (Nandrolone Decanoate)
19-nor · t½ 6-12 days (apparent depot terminal half-life; free nandrolone elimination ~4.3h after de-esterification; Minto CF et al. 1997 PMID 9103484)
Dianabol (Methandrostenolone)
Orals · t½ 3-6 hours
Monitoring (Bloodwork & Vitals)
- Comprehensive metabolic panel (baseline, mid-cycle, post-cycle)
- Lipid panel (total cholesterol, HDL, LDL, triglycerides)
- CBC (hemoglobin, hematocrit — watch for erythrocytosis)
- Sex-hormone panel (Total T, Free T, Estradiol sensitive, SHBG, LH, FSH)
- Blood pressure (weekly self-check; flag systolic >140 or diastolic >90)
Baseline bloodwork is recommended before any cycle. Discontinue if liver enzymes exceed 3× upper limit of normal or if hematocrit exceeds 54%.
Frequently Asked Questions
What is the half-life of Masteron Propionate?
Masteron Propionate has a half-life of approximately 2-3 days. Clearance estimate: 48h � 5 = 240h = 10 days. This figure is used to determine injection frequency (for esters) and post-cycle clearance timing.
What is the typical dose range for Masteron Propionate?
Commonly reported ranges for Masteron Propionate: 350-525mg/week. Cycle length: 8-12 weeks. These are compiled from published studies and community-reported usage — individual response varies and lower end is always preferred.
Does Masteron Propionate suppress natural testosterone?
Masteron Propionate causes moderate suppression of the HPTA axis (score 3/10). PCT may still be advisable depending on stack and duration.
Does Masteron Propionate aromatize to estrogen?
Aromatization profile: No. Minimal to no aromatization expected, so aromatase inhibitors are not typically indicated for this compound alone.
What is Masteron Propionate typically used for?
Masteron Propionate is commonly used for: Cutting, Contest prep, Intermediate users. Intended-use context does not imply safety — every use case carries the same underlying pharmacological risks.
Citations
- FDA prescribing information (NDA historical). 2004. FDA NDA (drostanolone propionate) — Half-life 2-2.5 days for propionate ester; FDA-approved for breast cancer
- Liu et al.. 2025. Substance Use & Misuse — AAS meta-analysis: SBP +12.43 mmHg (95% CI: 9.59-15.26), LDL-C +9.12 mg/dL (95% CI: 6.75-11.49)
- Hartgens F, Kuipers H. Effects of androgenic-anabolic steroids in athletes. Sports Med 2004
Disclaimer
StackItSmart is an independent harm-reduction reference. The content above is compiled from peer-reviewed literature and is not medical advice, not an endorsement, and not a recommendation to use Masteron Propionate. Performance-enhancing compounds carry legal, endocrine, cardiovascular, and hepatic risks. Consult a licensed clinician before any decision. StackItSmart does not provide sourcing, procurement, or dosing prescriptions.