Ipamorelin — Dosing, Cycles, Half-Life & Side Effects
Ipamorelin is a growth hormone releasing peptide (GHRP) with a half-life of 2-3 hours. Selective GHRP that stimulates GH release without significant increases in cortisol, prolactin, or appetite. Considered the cleanest GHRP with minimal side effects. This page is educational harm-reduction reference compiled from peer-reviewed literature — not medical advice, not an endorsement, not a recommendation to use. Consult a licensed clinician before any decision.
Quick Facts
| Class | Growth Hormone Releasing Peptide |
|---|---|
| Half-life | 2-3 hours |
| Hepatotoxicity | None |
| Suppression | 0/10 |
Typical Dosing Ranges
Common dose range: 200-300mcg 2-3x/day (ideally with CJC-1295)
Cycle length: 8-16 weeks
Dose ranges are compiled from published pharmacokinetic studies and community-reported usage. Where a value is community-reported rather than clinically studied, this page and its structured data flag it. Lower end of any range is always the safer starting point.
Stacking Considerations
- No structural stacking blockers. Standard harm-reduction rules apply: minimize total androgen load, minimize oral exposure, and monitor bloodwork.
PCT Requirements
- Never stack two SERMs. Extend a single SERM (tamoxifen OR enclomiphene/clomiphene) rather than combining.
- Use the cycle planner to generate a full protocol based on your complete stack, not this compound alone.
Side Effect Profile
- Less potent GH release than GHRP-2/6
- Requires injection
- Best results when combined with GHRH
- Multiple daily doses needed
Known Interactions
No compound-specific interactions are catalogued in the current matrix. This does not mean no risk exists — it means there is no curated pairwise entry. Browse the full interaction matrix to cross-reference manually.
Related compounds
Monitoring (Bloodwork & Vitals)
- Comprehensive metabolic panel (baseline, mid-cycle, post-cycle)
- Lipid panel (total cholesterol, HDL, LDL, triglycerides)
- CBC (hemoglobin, hematocrit — watch for erythrocytosis)
- Sex-hormone panel (Total T, Free T, Estradiol sensitive, SHBG, LH, FSH)
- Blood pressure (weekly self-check; flag systolic >140 or diastolic >90)
Baseline bloodwork is recommended before any cycle. Discontinue if liver enzymes exceed 3× upper limit of normal or if hematocrit exceeds 54%.
Frequently Asked Questions
What is the half-life of Ipamorelin?
Ipamorelin has a half-life of approximately 2-3 hours. This figure is used to determine injection frequency (for esters) and post-cycle clearance timing.
What is the typical dose range for Ipamorelin?
Commonly reported ranges for Ipamorelin: 200-300mcg 2-3x/day (ideally with CJC-1295). Cycle length: 8-16 weeks. These are compiled from published studies and community-reported usage — individual response varies and lower end is always preferred.
Does Ipamorelin suppress natural testosterone?
Ipamorelin causes minimal suppression of the HPTA axis (score 0/10). PCT may still be advisable depending on stack and duration.
What is Ipamorelin typically used for?
Ipamorelin is commonly used for: Recovery, Anti-aging, Body composition, Sleep enhancement. Intended-use context does not imply safety — every use case carries the same underlying pharmacological risks.
Is Ipamorelin legal?
Ipamorelin is a controlled substance in many jurisdictions (typically Schedule III in the US when it is an anabolic androgenic steroid). StackItSmart does not provide sourcing information. Possession, import, and use without a prescription carry legal consequences that vary by country and state.
Citations
- Gobburu JV et al.. 1999. J Pharm Sci — Ipamorelin PK: most selective GHRP, no ACTH/cortisol/prolactin effects
- Greenwood-Van Meerveld B et al.. 2014. Neurogastroenterol Motil — Phase II RCT for postoperative ileus
- Raun K, et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998;139(5):552-61. PMID: 9849822
Disclaimer
StackItSmart is an independent harm-reduction reference. The content above is compiled from peer-reviewed literature and is not medical advice, not an endorsement, and not a recommendation to use Ipamorelin. Performance-enhancing compounds carry legal, endocrine, cardiovascular, and hepatic risks. Consult a licensed clinician before any decision. StackItSmart does not provide sourcing, procurement, or dosing prescriptions.